Provider eNews
January 2007

 

Supporting Research by:

By: Robert Roy Britt

 

The Human Brain Seen as Master of Time

Your brain is a time machine with three modes that control everything from instantaneous tasks like moving to maintaining long trains of thought and ultimately staying in synch with night and day.

That's what scientists say. But they have no clue how most of it works.

Focusing on the poorly understood middle time zone, where the brain does some of its best work, researchers at Duke University summarize this latest thinking in a new article in the journal Nature Reviews Neuroscience.

Scientists have long understood human and animal brains to be governed in part by a circadian clock, which keeps us in synch with night and day. The rhythm of this 24-hour clock encourages nighttime sleep and allows many people to awaken with no help from a rooster.

Another clock is thought to operate at the millisecond level, controlling movement, speech and other vital functions that occur so quickly we don't really think about them.

But in between, there must be a third timekeeper of the mind to aid all the functions that require seconds to minutes of attention. Nobody is sure about this, though.

Interval timing

Duke neuroscientists Warren Meck and Catalin Buhusi call the middle mode "interval timing."

"To understand speech, I not only have to process the millisecond intervals involved in voice onset time, but also the duration of vowels and consonants," Meck said Friday. "Also, to respond, I need to process the pacing of speech, to organize my thoughts coherently and to respond back to you in a timely manner."

Interval timing has not been studied in detail. In fact it may be very hard to look into it.

Meck has been pondering it since the 1980s, but little progress has been made in pinning down how it works. He suspects the interval-timing clock does not reside in a single location, as is the case with smell, taste and other senses. Even the circadian clock is located in one part of the brain.

But interval timing "has to be distributed so it can integrate information from all the senses," Meck said today.

Figuring out how it works may turn out to be more important in understanding the brain that the spatial connections between various parts of the brain.

"I would argue that time is more fundamental than space, because one can just close one's eyes and relive memories, going back in time," Buhusi says, "or prospectively go forward in time to predict something, without actually changing your position in space."

The conductor and his orchestra

Theorists used to think interval timing was orchestrated by some sort of biological pacemaker that emitted timing pulses.

The new thinking is that the various parts of the brain oscillate and all these oscillations are monitored and integrated by certain circuits, perhaps in the basal ganglia, an area of the brain that controls basic functions such as movement.

"It's like a conductor who listens to the orchestra, which is composed of individual musicians," Buhusi explains. "Then, with the beat of his baton, the conductor synchronizes the orchestra so that listeners hear a coordinated sound."

The new paper by Meck and Buhusi lists the various challenges to cracking the interval timing mechanism and outlines techniques being employed. As with many attempts to understand the brain, researchers are looking at what happens when it stops working normally.

"When Parkinson's patients are on their medication, they time quite normally," Meck said. "But as their medication wears off, we can see their clock slow down by recording their brain signals."
 

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07:45 - 08:00 Introduction to Theory and Equipment
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Learn the answers to Frequently Asked Clinical Questions

Clinical Questions Answered Here
Get answers to your clinical questions here. Also be sure to visit the provider login section of the website and use the FAQ/Best Practices tool. This exciting new feature lets you search for answers to IM questions by Diagnosis, Deficit, or both.
 


Due to IM’s impact on cortical and subcortical structures of the brain, it can have a positive effect on a patient’s ability to self-regulate behavior.

Q: Can IM improve a patient’s behavior?

A: Due to IM’s impact on cortical and subcortical structures of the brain, it can have a positive effect on a patient’s ability to self-regulate behavior.  (Alpiner, 2004)  IM has been reported to decrease aggressive behavior in children with Attention Deficit/Hyperactivity Disorder (Shaffer et al., 1999).

The frontal lobes are responsible for action (Hale & Fiorrello, 2004; Duncan et al., 1995; Duncan et al., 1996).  Research has implicated the frontal lobes as the possible location of a “mental time-keeper” (Meck, 1983; Meck et al., 1984; Papagno et al., 2004).  The prefrontal cortex has a high degree of interconnectivity (with other parts of the brain).  This allows the prefrontal cortex to integrate input from many sources in order to implement more abstract behaviors.  It is uniquely oriented to time (Huey et al., 2006). 

The dorsolateral prefrontal cortex is the highest cortical area responsible for motor planning, organization, and regulation (Hale & Fiorello, 2004).  It has rich connections with the basal ganglia and limbic system. The basal ganglia is involved in the generation of goal-directed voluntary movement (VandenBos, 2006).  Converging evidence has implicated the role of the basal ganglia, operating via the frontal-striatal loop, in mental timing functions (Janata & Grafton, 2003; Nobre & O’Reilly, 2004; Peretz & Zatorre, 2005).
 



IM is widely and successfully used to improve central vestibular and balance function in individuals of all ages.

Q: How is IM used to improve balance and vestibular function in children?

A: IM is widely and successfully used to improve central vestibular and balance function in individuals of all ages. 

Dr. Kevin McGrew, a noted researcher, has tapped into neuroscience and music literature to help us to understand why IM, which is such a simple timing intervention, "can produce improvements across such diverse human performance domains."  To give some insight on why it is an effective tool for balance and vestibular function, here is just some of the information from recent IM and neuroscientific research:

Research conducted by Dr. Neal Alpiner, which examined the brains of IM-trained individuals under fMRI during simulated IM tasks then compared them to a non-trained control, found that those individuals that were trained in IM exhibited more activity of advanced brain structures than the control during IM.  Key brain structures involved included: the cerebellum, prefrontal cortex, basal ganglia, and cingulate gyrus.  The cerebellum is associated with sense of body position (balance, posture, eye movement) (Hale & Fiorello, 2004).  It is also involved in coordinated motor acquisition (Debaere et al., 2001).  And it seems to be involved in timing (Ivry, 1993; Janata & Grafton, 2003; Nobre & O'Reilly, 2004; Peretz & Zatorre, 2005; Rapoport et al., 2000).  

The dorsolateral prefrontal cortex is responsible for motor planning and has rich connections to the basal ganglia (Hale & Fiorello, 2004).  The prefrontal cortex is uniquely oriented to time. (Huey et al., 2006)

The basal ganglia is involved in the generation of goal-directed voluntary movement (VandenBos, 2006).  It is also involved in motor function (posture, tone, motor activity, response coordination, sequencing, control of ongoing movement).  (Cassidy et al., 2002; Hale & Fiorello, 2004; Middleton & Strick, 2000).  The basal ganglia has rich connections to the cerebellum  and is significantly involved in motor planning, sensory performance, and sensorimotor integration (Diamond, 2003).  Evidence is implicating the role of the basal ganglia in mental-timing functions (Janata & Grafton, 2003; Nobre & O'Reilly, 2004; Peretz & Zatorre, 2005).

As you can see, many of the structures involved in vestibular and balance functioning are associated with these time-keeping structures of the brain.  The fMRI study has implicated the effect of IM on these brain structures, which may help explain why IM is such an effective intervention tool for these types of problems. 

Thank you for your question.  Please let me know if I can be of further assistance to you by emailing me at the address below.

Footnote:  Some of the contents of this response was taken from Kevin McGrew, Ph.D., Institute for Applied Psychometrics, The Synchronized Metronome Tapping (SMT) Effect: Preliminary thoughts on "what's happening under the hood", 2006
 

Have Clinical questions of your own? E-mail Clinical Education Director, Amy Vega, for the answer at avega@interactivemetronome.com.
 


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